wrinkle

reducers

STILL YOU. WITH FEWER LINES.

ONLY BOTOX® COSMETIC IS FDA APPROVED TO TEMPORARILY MAKE MODERATE TO SEVERE FROWN LINES, CROW’S FEET, AND FOREHEAD LINES LOOK BETTER IN ADULTS.

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THE ONE AND ONLY BOTOX® COSMETIC

ONLY BOTOX® COSMETIC IS FDA APPROVED TO TEMPORARILY MAKE MODERATE TO SEVERE FROWN LINES, CROW’S FEET AND FOREHEAD LINES LOOK BETTER IN ADULTS.

THE ONE AND ONLY BOTOX® COSMETIC

ONLY BOTOX® COSMETIC IS FDA APPROVED TO TEMPORARILY MAKE MODERATE TO SEVERE FROWN LINES, CROW’S FEET AND FOREHEAD LINES LOOK BETTER IN ADULTS.

WHAT IS DYSPORT®?

Natural-looking. Fast-acting. Long-lasting.

Don’t let your frown lines between your eyebrows define you. For adults who want a natural look, Dysport is a natural-looking, fast-acting1-3, long-lasting1,2,4 prescription injection proven to help smooth moderate to severe frown lines between the eyebrows—without changing the look or movement of the rest of your face.

Dysport is approved in 69 countries5 and has 25 years of clinical experience worldwide.6* Find out why 97% of women treated with Dysport say they’d do it again.7†‡

*Includes therapeutic and aesthetic uses.
†Subject’s satisfaction and self-perception reported 3 weeks after treatment (n=531).
‡Design: Multicenter, prospective, non-interventional observational study conducted in France, Germany, Spain and the United Kingdom (n=533). Subjects were eligible if the investigator had decided to prescribe Dysport according to the labeling. Subjects completed questionnaires at 3 weeks and 4 months after treatment.

How does Dysport work?

One injection. Five points.

Dysport temporarily treats moderate to severe frown lines between the eyebrows by reducing specific muscle activity.

Wrinkles are caused by repeated movements and muscle contractions.7 One injection into each of the 5 points between and above the eyebrows temporarily prevents muscle contractions that cause frown lines.

In other words: natural-looking results that look and feel like you.

Results when you need them.

Fast-Acting

Over half of users see improvement 2‐3 days after Dysport® injection for frown lines between the brows.

Results typically appear
2-3 days after treatment.1-3§

Long-Lasting

Long‐lasting: Dysport® injection results (smoother frown lines between the brows) may last up to 5 months.

Results may last up to
5 months.1-3§

 

You’ve got better things to do than think about what your frown lines look like. The majority of users see improvement in just 2-3 days after treatment. In just one 10- to 20-minute treatment, Dysport may help improve the look of your frown lines between the eybrows for up to 5 months.2-4‖ Results of repeat treatments may be comparable to your first use. Another plus? There is minimal downtime after your treatment, which means you can get back to your day faster.

Dysport users¶ were satisfied with their results– and with only two treatments per year.8#

0
OF USERS¶

were satisfied with only
2 treatments per year.8#

 

0
OF USERS¶

were satisfied with only
2 treatments per year.8#

 

0
OF USERS¶

were satisfied with only
2 treatments per year.8#

 

Who should use Dysport?

See if it’s right for you.

If you’re under 65 and seeking treatment to temporarily improve the look of wrinkles between the eyebrows, ask your specialist if Dysport is right for you. But before you begin, read below to help you make the safest, most informed decision.

 

  • *Includes therapeutic and aesthetic uses.
  • †Subject’s satisfaction and self-perception reported 3 weeks after treatment (n=531).
  • ‡Design: Multicenter, prospective, non-interventional observational study conducted in France, Germany, Spain, and the United Kingdom (n=533). Subjects were eligible if the investigator had decided to prescribe Dysport according to the labeling. Subjects completed questionnaires at 3 weeks and 4 months after treatment.
  • §A secondary endpoint based on Kaplan-Meier estimates of cumulative rate of time to onset of response. The median time to onset of response was 3 days in GL-1 (Dysport 55/105 [52%], Placebo 3/53 [6%]) and GL-2 (Dysport 36/71 [51%], Placebo 9/71 [13%]), and 2 days in GL-3 (Dysport 110/200 [55%], Placebo 4/100 [4%]).
  • ‖GL-1 and GL-3 evaluated subjects for at least 150 days following treatment. Based on a ≥1-Grade GLSS improvement from baseline utilizing data from two double-blinded, randomized, placebo-controlled pivotal studies (GL-1, GL-3) in a post-hoc analysis.
  • Users = clinical trial subjects.
  • #Subject-reported at 12 months (N=120) after two treatments six months apart in a phase IV, multicenter, prospective study.
  • **3 out of 10 FACE-Q questions about psychological function are shown.

References

  1. Data on file. GL-Y-97-52120-085 (GL-2) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  2. Data on file. GL-Y-97-52120-719 (GL-1) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  3. Data on file. GL-Y-97-52120-718 (GL-3) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  4. Data on file. MA-35497. Post Hoc Analysis. Fort Worth, TX: Galderma Laboratories, L.P., 2017.
  5. Data on file. Ipsen World-Wide Marketing Authorisation Status. Fort Worth, TX: Galderma Laboratories, L.P., February 2017.
  6. Medicines and Healthcare products Regulatory Agency (MHRA). Botulinum Toxin Type A Powder For Solution For Injection (Clostridium botulinum toxin type A – Haemagglutinin complex). Accessed December 6, 2019.
  7. Molina B, Grangier Y, Mole B, et al. Patient satisfaction after the treatment of glabellar lines with Botulinum toxin type A (Speywood Unit): a multi-centre European observational study. J Eur Acad Dermatol Venereol. 2015;29(7):1382-1388.
  8. Data on file. 43USD1802 Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2020.

DO NOT TAKE DYSPORT IF YOU:

  • Are allergic to Dysport or any of the ingredients in Dysport. See the end of the Dysport Medication Guide for a list of ingredients in Dysport
  • Are allergic to cow’s milk protein
  • Had an allergic reaction to any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA) or Xeomin® (incobotulinumtoxinA)
  • Have a skin infection at the planned injection site

DYSPORT MAY NOT BE RIGHT FOR YOU IF:

  • You have had surgical changes to your face
  • You have very weak muscles in the treatment area
  • Your face looks very different from side to side
  • The injection site is inflamed
  • You have droopy eyelids or sagging eyelid folds
  • You have deep facial scars
  • You have thick, oily skin
  • Your wrinkles can’t be smoothed by spreading them apart

The only way to know for sure if Dysport is right for you is to speak with your healthcare provider. Don’t have one? Find a specialist near you who administers Dysport.

See below for Dysport Important Safety Information, including Boxed Warning, and Medication Guide.

IMPORTANT SAFETY INFORMATION

Dysport® (abobotulinumtoxinA) is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age.

Important Safety Information

What is the most important information you should know about Dysport? Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect areas of the body away from the injection site. Symptoms can happen hours to weeks after injection and may include swallowing and breathing problems, loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there have been reports of death. You are at the highest risk if these problems are pre‐existing before injection.

These effects could make it unsafe for you to drive a car, operate machinery, or do other dangerous activities.

Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®, have a skin infection at the planned injection site, under 18 years of age, or are pregnant or breastfeeding.

The dose of Dysport is not the same as the dose of any other botulinum toxin product and cannot be compared to the dose of any other product you may have used.

Tell your doctor about any swallowing or breathing difficulties and all your muscle or nerve conditions such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis, or Lambert‐Eaton syndrome, which may increase the risk of serious side effects including difficulty swallowing and difficulty breathing. Serious allergic reactions have occurred with the use of Dysport. Dry eye has also been reported.

Tell your doctor about all of your medical conditions, including if you have surgical changes to your face, very weak muscles in the treatment area, any abnormal facial change, injection site inflammation, droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, wrinkles that can’t be smoothed by spreading them apart, or if you are pregnant or breastfeeding or planning to become pregnant or breastfeed.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause serious side effects. Do not start any new medicines while taking Dysport without talking to your doctor first.

Especially tell your doctor if you: have received any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA), in the last four months or any in the past (be sure your doctor knows exactly which product you received), have recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take a sleep medicine.

Common Side Effects

The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.

Ask your doctor if Dysport is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Dysport Full Prescribing Information including Medication Guide at DysportUSA.com.

 

Beauty is dynamic.

Your filler should be, too.

Why the RHA® Collection?

The RHA® Collection of dermal fillers is designed for natural-looking results.

DYNAMIC

Made to adapt to your dynamic facial movements for a look that’s beautiful at rest and flawless in motion.

 

NATURAL

Formulated to more closely resemble the natural hyaluronic acid (HA) in your skin.

 

MEET THE LATEST ADVANCEMENT IN THE COLLECTION

RHA RedensityTM

The weightless lipstick-line treatment for dynamic lines around the mouth.

Find out why the RHA® Collection is an award-winning line of designer fillers

FACE YOUR DAY

YOUR WAY

JUVÉDERM® is the #1 chosen dermal filler collection in the US* that offers 5 different and long lasting fillers. Each one adds volume and is designed for different needs in different areas of the face including lips, cheeks, or chin depending on your unique needs. We have what you need to get the results you want.

ALL ABOUT JUVÉDERM®

Hyaluronic acid, or HA, is a naturally occurring substance that delivers volume to the skin. JUVÉDERM® is a long-lasting, non-surgical option that contains a modified form of HA. Fillers that include HA are a top choice for patients—over 90% of filler patients receive an HA dermal filler.*

 

CLICK TO EXPLORE YOUR TREATMENT OPTIONS

JUVÉDERM® INJECTABLE GEL FILLERS IMPORTANT INFORMATION

APPROVED USES

JUVÉDERM® VOLUXTM XC injectable gel is for deep injection to improve moderate to severe loss of jawline definition in adults over the age of 21.

JUVÉDERM® VOLUMA® XC injectable gel is for deep injection in the cheek area to correct age-related volume loss and for augmentation of the chin region to improve the chin profile in adults over 21.

JUVÉDERM® VOLLURE® XC, JUVÉDERM® Ultra Plus XC, and JUVÉDERM® Ultra XC injectable gels are for injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. JUVÉDERM® VOLLURE® XC injectable gel is for adults over 21.

JUVÉDERM® Ultra XC injectable gel is also for injection into the lips and perioral area for lip augmentation in adults over 21.

JUVÉDERM® VOLBELLA® XC injectable gel is for injection into the lips for lip augmentation and correction of perioral lines, and for injection into the undereye hollows to improve the appearance of undereye hollows in adults over the age of 21.

IMPORTANT SAFETY INFORMATION

ARE THERE ANY REASONS WHY I SHOULD NOT RECEIVE ANY JUVÉDERM® FORMULATION?

Do not use these products if you have a history of multiple severe allergies or severe allergic reactions (anaphylaxis), if you are allergic to lidocaine or the Gram-positive bacterial proteins used in these products, or if you have had previous allergic reactions to hyaluronic acid fillers.

WHAT WARNINGS SHOULD MY DOCTOR ADVISE ME ABOUT?

  • One of the risks with using dermal fillers is the unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. Most of these events are irreversible.

  • If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.

  • The use of dermal fillers where skin sores, pimples, rashes, hives, cysts, or infections are present should be postponed, as this may delay healing or make skin problems worse

  • The effectiveness of removal of any dermal filler has not been studied.

 

WHAT PRECAUTIONS SHOULD MY DOCTOR ADVISE ME ABOUT?

  • JUVÉDERM® VOLBELLA® XC should only be injected into undereye hollows by doctors who have completed the necessary training for this treatment area. To find a doctor, visit Juvederm.com/find-a-specialist. Doctors who complete the training will be listed with a symbol

  • The safety of these products for use during pregnancy or while breastfeeding has not been studied

  • The safety of JUVÉDERM® VOLUMA® XC has not been studied in patients under 35 years or over 65 years for cheek augmentation, or under 22 years and over 80 years for chin augmentation. The safety of JUVÉDERM® VOLUX™ XC, JUVÉDERM® VOLLURE® XC and JUVÉDERM® VOLBELLA® XC has not been studied in patients under 22 years, and the safety of JUVÉDERM® Ultra Plus XC and JUVÉDERM® Ultra XC has not been studied in patients under 18 years

  • The safety and effectiveness of treatment with JUVÉDERM® products in anatomical regions outside of their approved uses have not been established in clinical studies

  • If you have a history of excessive scarring (thick, hard scars) or pigmentation disorders, treatment in these patients has not been studied and may result in additional scars or changes in pigmentation

  • If you are planning other procedures including laser treatments or a chemical peel, there is a possible risk of inflammation at the treatment site if these procedures are performed closely before or after JUVÉDERM® injectable gel treatment

  • Tell your doctor if you are on therapy used to reduce your body’s natural defense system (such as steroids, chemotherapy, and medicines to treat autoimmune diseases, HIV, and AIDs), as these may increase your risk of infection; and medications that can prolong bleeding (such as aspirin, ibuprofen, or other blood thinners), as these may result in increased bruising or bleeding at the injection site.

  • Avoid applying makeup for 12 hours after treatment and minimize strenuous exercise, exposure to extensive sun or heat, and alcoholic beverages within the first 24 hours following treatment, as these may cause temporary redness, swelling, and/or itching at the injection site

  • JUVÉDERM® VOLUMA® XC was not studied in patients with significant loose skin of the chin, neck, or jaw

  • The effect of JUVÉDERM® VOLUMA® XC injection into the chin on facial hair growth has not been studied

  • Patients who experience skin injury near the site of JUVÉDERM® VOLUMA® XC injection may be at a higher risk for adverse events

  • Tell your doctor if you have already been injected with dermal fillers in the same area as the one(s) you are about to be treated for. This information helps your doctor decide when and whether you should get treatment

WHAT ARE POSSIBLE SIDE EFFECTS OF TREATMENT?

The most commonly reported side effects with JUVÉDERM® injectable gels were redness, swelling, pain, tenderness, firmness, lumps/bumps, bruising, discoloration, and itching. For JUVÉDERM® VOLBELLA® XC, dryness was also reported.

These side effects are consistent with other facial injection procedures and most will resolve within 30 days. Your doctor may choose to treat side effects persisting longer with antibiotics, steroids, or hyaluronidase (an enzyme that breaks down hyaluronic acid).

As with all skin injection procedures, there is a risk of infection.

To report a side effect with any product in the JUVÉDERM® Collection, please call the Allergan® Product Support Department at 1-877-345-5372. Please also visit Juvederm.com or talk to your doctor for more information.

Products in the JUVÉDERM® Collection are available only by a licensed physician or properly licensed practitioner.

Revanesse

What is Revanesse Versa+?

Revanesse Versa is an FDA approved hyaluronic acid dermal filler that can be used to treat moderate to severe facial wrinkles and folds, including nasolabial folds in patients 22 years of age or older.

What is Revanesse Lips+?

Revanesse Lips+ is an FDA approved hyaluronic acid dermal filler that can be used to submucosal implantation for lip augmentation in patients 22 years of age or older.

THE NEW 1.2 ML SYRINGE – A little more goes a long way!

Revanesse is the only hyaluronic acid (HA) dermal filler in the US available in a 1.2mL syringe size. Whether you require more product to be brought to full correction or are seeking a more cost-effective treatment option; 20% more product in our syringe is another example of the Revanesse difference and our commitment to providing pathways for patients to achieve the best possible results.

Headquartered in Ontario, Canada, Prollenium is committed exclusively to the development and global commercialization of the Revanesse brand of hyaluronic acid (HA) dermal fillers and is reshaping the aesthetic experience.

Our investment into research and development, from our unique cross-linking processes, to the spherical nature of our particles, has led to cutting-edge advancements designed to enhance the
treatment outcomes for dermal filler patients and aesthetic providers. Having sold close to 6 million syringes worldwide, the Revanesse family of products are now present in over 90 countries around the globe.

LESS SWELLING

In one of our clinical trials, 50% more patients treated with a comparative produce experienced swelling, than patients who were treated with Revanesse Versa.

LONGEVITY

You may find that Revanesse Versa will in the improvement of your nasolabial folds (laugh lines) for up to 12 months with optimal correction.

DESIGNED FOR SAFETY

The Revanesse Versa formula is well-studied, with over 300 patients of multiple skin types, treated in three clinical trials, with no serious adverse events reported.

IMMEDIATE RESULTS

A Revanesse Versa+ treatment is minimally invasive and provides immediate results. Take control of the signs of aging and ask your healthcare provider if Revanesse Versa+ is right for you!

How long does Revanesse® Lips™+ last?

The length of time for lip augmentation and wrinkle correction varies. Many people maintain correction at six months. In the clinical study, sixty five percent of patients (35/54) treated with Revanesse® Lips™+ rated themselves as much improved or very much improved at Month 6 after injection. Revanesse® Lips™+ is absorbed by the body over time.

What happens before the procedure?

Your doctor will examine you and will explain the procedure and the potential risks. You will be asked about your health, your medical history, and the medications you take and have recently taken. You
should advise your doctor of any of your concerns before the procedure, and discuss any questions related to the procedure.

What should I expect after the procedure?

Following treatment, a cold compress or ice may be applied for any bruising or swelling at the injection site. You may also gently massage the area with constant pressure for several minutes. The most
common side effects include bruising, redness, swelling, pain, and itching.

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